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eugenegpдля дальнейших дискуссий - чтоб были под рукой - выношу несколько относительно свежих исследований успешности гомеопатической терапии (рандомизированных двойных слепых клинических, с плацебо или препаратом сравнения)
Homeopathic treatment of mild traumatic brain injury: A randomized, double-blind, placebo-controlled clinical trial.
J Head Trauma Rehabil 1999 Dec;14(6):521-42 (ISSN: 0885-9701)
Chapman EH; Weintraub RJ; Milburn MA; Pirozzi TO; Woo E
Harvard University School of Medicine, Boston, MA, USA.
BACKGROUND: Mild traumatic brain injury (MTBI) affects 750,000 persons in the United States annually. Five to fifteen percent have persistent dysfunction and disability. No effective, standard pharmacological treatment exists specifically for this problem. We designed a pilot research project to study the clinical effectiveness of homeopathic medicine in the treatment of persistent MTBI. METHOD: A randomized, double-blind, placebo-controlled trial of 60 patients, with a four-month follow-up (N = 50), was conducted at Spaulding Rehabilitation Hospital (SRH). Patients with persistent MTBI (mean 2.93 years since injury, SD 3.1) were randomly assigned to receive a homeopathic medicine or placebo. The primary outcome measure was the subject-rated SRH-MBTI Functional Assessment, composed of three subtests: a Difficulty with Situations Scale (DSS), a Symptom Rating Scale (SRS), and a Participation in Daily Activities Scale (PDAS). The SRH Cognitive-Linguistic Test Battery was used as the secondary measure. RESULTS: Analysis of covariance demonstrated that the homeopathic treatment was the only significant or near-significant predictor of improvement on DSS subtests (P =.009; 95% CI -.895 to -.15), SRS (P =.058; 95% CI -.548 to.01) and the Ten Most Common Symptoms of MTBI (P =.027; 95% CI -.766 to -.048). These results indicate a significant improvement from the homeopathic treatment versus the control and translate into clinically significant outcomes. CONCLUSIONS: This study suggests that homeopathy may have a role in treating persistent MTBI. Our findings require large-scale, independent replication.
=======
A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation.
Cancer 2001 Aug 1;92(3):684-90 (ISSN: 0008-543X)
Oberbaum M; Yaniv I; Ben-Gal Y; Stein J; Ben-Zvi N; Freedman LS; Branski D
BACKGROUND: Stomatitis is a common consequence of chemotherapy and a condition for which there is little effective treatment. Although the management of patients with other chemotherapy-related toxicities has improved in recent years, the incidence of stomatitis is increasing because of more intensive treatment and is often a dose limiting factor in chemotherapy. The authors assessed the efficacy of a homeopathic remedy, TRAUMEEL S(R), in the management of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation. METHODS: A randomized, placebo-controlled, double-blind clinical trial was conducted in 32 patients ages 3-25 years who had undergone allogeneic (16 patients) or autologous (16 patients) stem cell transplantation. Of the 30 evaluable patients, 15 were assigned placebo, and 15 were assigned TRAUMEEL S both as a mouth rinse, administered five times daily from 2 days after transplantation for a minimum of 14 days, or until at least 2 days after all signs of stomatitis were absent. Stomatitis scores were evaluated according to the World Health Organization grading system for mucositis. RESULTS: A total of five patients (33%) in the TRAUMEEL S treatment group did not develop stomatitis compared with only one patient (7%) in the placebo group. Stomatitis worsened in only 7 patients (47%) in the TRAUMEEL S treatment group compared with 14 patients (93%) in the placebo group. The mean area under the curve stomatitis scores were 10.4 in the TRAUMEEL S treatment group and 24.3 in the placebo group. This difference was statistically significant (P < 0.01). CONCLUSIONS: This study indicates that TRAUMEEL S may reduce significantly the severity and duration of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation.
=====
A randomized controlled trial comparing topical piroxicam gel with a homeopathic gel in osteoarthritis of the knee.
Rheumatology (Oxford) 2000 Jul;39(7):714-9 (ISSN: 1462-0324)
van Haselen RA; Fisher PA
OBJECTIVE.: To evaluate the efficacy and safety of a homeopathic gel vs an NSAID (piroxicam) gel in the treatment of osteoarthritis of the knee. METHOD.: One hundred and eighty-four out-patients with radiographically confirmed symptomatic osteoarthritis of the knee were entered into a pragmatic, randomized, double-blind controlled trial and treated with 1 g of gel three times daily for 4 weeks. Main outcome measures were pain on walking as a Visual Analogue Score (VAS) and a single-joint Ritchie index. RESULTS.: One hundred and seventy-two of the 184 enrolled patients had endpoints for the main outcome parameters. The pain reduction was 16.5 mm VAS in the homeopathy group (n = 86) and 8.1 mm in the piroxicam group (n = 86); the difference between treatment groups was 8.4 mm (95% confidence interval 0.8-15.9), and after adjustment for pain at baseline it was 6.8 mm (95% confidence interval -0.3 to 13.8). There was no significant difference between treatment groups in the single-joint Ritchie index (P = 0.78). Adverse events occurred in 28 patients (12 homeopathy group, 5 withdrawn; 16 piroxicam group, 9 withdrawn); 18 of the events involved a local reaction (7 homeopathy group, 2 withdrawn; 11 piroxicam group, 5 withdrawn). CONCLUSION.: The homeopathic gel was at least as effective and as well tolerated as the NSAID gel. The presence of a clinically relevant difference between treatment groups cannot be excluded. The homeopathic gel supplemented by simple analgesics if required may provide a useful treatment option for patients with osteoarthritis.
=================
[Treatment of pain due to unwanted lactation with a homeopathic preparation given in the immediate post-partum period]
[Traitement de la douleur de la montee laiteuse non souhaitee par homeopathie dans le post-partum immediat.]
J Gynecol Obstet Biol Reprod (Paris) 2001 Jun;30(4):353-7 (ISSN: 0368-2315)
Berrebi A; Parant O; Ferval F; Thene M; Ayoubi JM; Connan L; Belon P
Federation de Gynecologie-Obstetrique, Service de Pharmacie, CHU La Grave, 31052 Toulouse Cedex, France.
Dopaminergic agonists, such as Parlodel((R)), are now widely used to inhibit lactation. However, some countries, such as the United States, no longer use these drugs in this indication because of their sometimes serious adverse effects. In this context, the authors tested a homeopathic treatment designed for parturients unable or not wanting to breastfeed. The APIS MELLIFICA 9 CH and BRYONIA 9 CH combination was chosen for its anti-inflammatory and analgesic effects. 71 patients were included in this double-blind placebo-controlled study. All received basic treatment comprising naproxen and fluid restriction. A significant improvement of lactation pain (main criterion of the study) was observed in parturients treated with homeopathy (p<0.02 on D2 and p<0.01 on D4). A similar effect (p<0.05 on D4) was observed for breast tension and spontaneous milk flow. No significant difference was observed for the other criteria of the study. The homeopathic combination studied was therefore effective on the pain of lactation and should be integrated into the therapeutic armamentarium.
====
Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo
Rheumatology (Oxford) 2004 May;43(5):577-82 (ISSN: 1462-0324)
Bell IR; Lewis DA; Brooks AJ; Schwartz GE; Lewis SE; Walsh BT; Baldwin CM
Objective. To assess the efficacy of individualized classical homeopathy in the treatment of fibromyalgia. Methods. This study was a double-blind, randomized, parallel-group, placebo-controlled trial of homeopathy. Community-recruited persons (N = 62) with physician-confirmed fibromyalgia (mean age 49 yr, s.d. 10 yr, 94% women) were treated in a homeopathic private practice setting. Participants were randomized to receive oral daily liquid LM (1/50 000) potencies with an individually chosen homeopathic remedy or an indistinguishable placebo. Homeopathic visits involved joint interviews and concurrence on remedy selection by two experienced homeopaths, at baseline, 2 months and 4 months (prior to a subsequent optional crossover phase of the study which is reported elsewhere). Tender point count and tender point pain on examination by a medical assessor uninvolved in providing care, self-rating scales on fibromyalgia-related quality of life, pain, mood and global health at baseline and 3 months, were the primary clinical outcome measures for this report. RESULTS: Fifty-three people completed the treatment protocol. Participants on active treatment showed significantly greater improvements in tender point count and tender point pain, quality of life, global health and a trend toward less depression compared with those on placebo. CONCLUSIONS: This study replicates and extends a previous 1-month placebo-controlled crossover study in fibromyalgia that pre-screened for only one homeopathic remedy. Using a broad selection of remedies and the flexible LM dose (1/50 000 dilution factor) series, the present study demonstrated that individualized homeopathy is significantly better than placebo in lessening tender point pain and improving the quality of life and global health of persons with fibromyalgia.
============
Beckmann-Reinhold A, Schauer U, Wellensiek B, Werner B, Wartenberg A
A homeopathic complex remedy proves efficacious in migraine therapy: a randomized, double blind, parallel group clinical trial.
Headache World, 2000 ;London. Sept 3-7
Objectives: To assess the efficacy and safety of a homeopathic complex remedy compared with placebo in patients with migraine.
Design: Randomized, double-blind, parallel group trial for 20 weeks. Run-in for 4 weeks, 12 weeks of medication and 4 weeks of follow-up examination. Additional, defined medication (triptane, analgesics) was allowed if necessary and was documented by patients in a diary, additionally in an electronic pain recorder system.
Participants: 70 migraine patients (both sexes) with minimum 4 migraine attacks per month. Duration of illness must be more than 1 year. Any migraine prophylaxis was excluded.
Intervention: A homeopathic mixture of Iris Dil.D3, Gelsemium Dil.D4, Cyclamen Dil.D4, Paris quadrifolia Dil.D4, and Asarum europaeum Dil.D4 (three times daily 15 drops) or placebo (three times daily 15 drops) or placebo (three times daily 15 drops).
Aim of treatment: Frequency of migraine attacks and decrease of defined medication.
Results: The main interim results, including 42 of 70 patients. Verum was more effective in decreasing frequency of migraine attacks and reducing defined medication (triptane, analgesics). These reductions were statistically significant. Evaluation of effectiveness and safety by doctors and patients was comparable and verum was significantly better than placebo.
Conclusion: Additional application of homeopathic complex remedy proved to be significant in reducing number of migraine attacks and led to a significant reduction of triptane and analgesics.
Далее - см. комменты, туда добавляются более свежие публикации.
Homeopathic treatment of mild traumatic brain injury: A randomized, double-blind, placebo-controlled clinical trial.
J Head Trauma Rehabil 1999 Dec;14(6):521-42 (ISSN: 0885-9701)
Chapman EH; Weintraub RJ; Milburn MA; Pirozzi TO; Woo E
Harvard University School of Medicine, Boston, MA, USA.
BACKGROUND: Mild traumatic brain injury (MTBI) affects 750,000 persons in the United States annually. Five to fifteen percent have persistent dysfunction and disability. No effective, standard pharmacological treatment exists specifically for this problem. We designed a pilot research project to study the clinical effectiveness of homeopathic medicine in the treatment of persistent MTBI. METHOD: A randomized, double-blind, placebo-controlled trial of 60 patients, with a four-month follow-up (N = 50), was conducted at Spaulding Rehabilitation Hospital (SRH). Patients with persistent MTBI (mean 2.93 years since injury, SD 3.1) were randomly assigned to receive a homeopathic medicine or placebo. The primary outcome measure was the subject-rated SRH-MBTI Functional Assessment, composed of three subtests: a Difficulty with Situations Scale (DSS), a Symptom Rating Scale (SRS), and a Participation in Daily Activities Scale (PDAS). The SRH Cognitive-Linguistic Test Battery was used as the secondary measure. RESULTS: Analysis of covariance demonstrated that the homeopathic treatment was the only significant or near-significant predictor of improvement on DSS subtests (P =.009; 95% CI -.895 to -.15), SRS (P =.058; 95% CI -.548 to.01) and the Ten Most Common Symptoms of MTBI (P =.027; 95% CI -.766 to -.048). These results indicate a significant improvement from the homeopathic treatment versus the control and translate into clinically significant outcomes. CONCLUSIONS: This study suggests that homeopathy may have a role in treating persistent MTBI. Our findings require large-scale, independent replication.
=======
A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation.
Cancer 2001 Aug 1;92(3):684-90 (ISSN: 0008-543X)
Oberbaum M; Yaniv I; Ben-Gal Y; Stein J; Ben-Zvi N; Freedman LS; Branski D
BACKGROUND: Stomatitis is a common consequence of chemotherapy and a condition for which there is little effective treatment. Although the management of patients with other chemotherapy-related toxicities has improved in recent years, the incidence of stomatitis is increasing because of more intensive treatment and is often a dose limiting factor in chemotherapy. The authors assessed the efficacy of a homeopathic remedy, TRAUMEEL S(R), in the management of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation. METHODS: A randomized, placebo-controlled, double-blind clinical trial was conducted in 32 patients ages 3-25 years who had undergone allogeneic (16 patients) or autologous (16 patients) stem cell transplantation. Of the 30 evaluable patients, 15 were assigned placebo, and 15 were assigned TRAUMEEL S both as a mouth rinse, administered five times daily from 2 days after transplantation for a minimum of 14 days, or until at least 2 days after all signs of stomatitis were absent. Stomatitis scores were evaluated according to the World Health Organization grading system for mucositis. RESULTS: A total of five patients (33%) in the TRAUMEEL S treatment group did not develop stomatitis compared with only one patient (7%) in the placebo group. Stomatitis worsened in only 7 patients (47%) in the TRAUMEEL S treatment group compared with 14 patients (93%) in the placebo group. The mean area under the curve stomatitis scores were 10.4 in the TRAUMEEL S treatment group and 24.3 in the placebo group. This difference was statistically significant (P < 0.01). CONCLUSIONS: This study indicates that TRAUMEEL S may reduce significantly the severity and duration of chemotherapy-induced stomatitis in children undergoing bone marrow transplantation.
=====
A randomized controlled trial comparing topical piroxicam gel with a homeopathic gel in osteoarthritis of the knee.
Rheumatology (Oxford) 2000 Jul;39(7):714-9 (ISSN: 1462-0324)
van Haselen RA; Fisher PA
OBJECTIVE.: To evaluate the efficacy and safety of a homeopathic gel vs an NSAID (piroxicam) gel in the treatment of osteoarthritis of the knee. METHOD.: One hundred and eighty-four out-patients with radiographically confirmed symptomatic osteoarthritis of the knee were entered into a pragmatic, randomized, double-blind controlled trial and treated with 1 g of gel three times daily for 4 weeks. Main outcome measures were pain on walking as a Visual Analogue Score (VAS) and a single-joint Ritchie index. RESULTS.: One hundred and seventy-two of the 184 enrolled patients had endpoints for the main outcome parameters. The pain reduction was 16.5 mm VAS in the homeopathy group (n = 86) and 8.1 mm in the piroxicam group (n = 86); the difference between treatment groups was 8.4 mm (95% confidence interval 0.8-15.9), and after adjustment for pain at baseline it was 6.8 mm (95% confidence interval -0.3 to 13.8). There was no significant difference between treatment groups in the single-joint Ritchie index (P = 0.78). Adverse events occurred in 28 patients (12 homeopathy group, 5 withdrawn; 16 piroxicam group, 9 withdrawn); 18 of the events involved a local reaction (7 homeopathy group, 2 withdrawn; 11 piroxicam group, 5 withdrawn). CONCLUSION.: The homeopathic gel was at least as effective and as well tolerated as the NSAID gel. The presence of a clinically relevant difference between treatment groups cannot be excluded. The homeopathic gel supplemented by simple analgesics if required may provide a useful treatment option for patients with osteoarthritis.
=================
[Treatment of pain due to unwanted lactation with a homeopathic preparation given in the immediate post-partum period]
[Traitement de la douleur de la montee laiteuse non souhaitee par homeopathie dans le post-partum immediat.]
J Gynecol Obstet Biol Reprod (Paris) 2001 Jun;30(4):353-7 (ISSN: 0368-2315)
Berrebi A; Parant O; Ferval F; Thene M; Ayoubi JM; Connan L; Belon P
Federation de Gynecologie-Obstetrique, Service de Pharmacie, CHU La Grave, 31052 Toulouse Cedex, France.
Dopaminergic agonists, such as Parlodel((R)), are now widely used to inhibit lactation. However, some countries, such as the United States, no longer use these drugs in this indication because of their sometimes serious adverse effects. In this context, the authors tested a homeopathic treatment designed for parturients unable or not wanting to breastfeed. The APIS MELLIFICA 9 CH and BRYONIA 9 CH combination was chosen for its anti-inflammatory and analgesic effects. 71 patients were included in this double-blind placebo-controlled study. All received basic treatment comprising naproxen and fluid restriction. A significant improvement of lactation pain (main criterion of the study) was observed in parturients treated with homeopathy (p<0.02 on D2 and p<0.01 on D4). A similar effect (p<0.05 on D4) was observed for breast tension and spontaneous milk flow. No significant difference was observed for the other criteria of the study. The homeopathic combination studied was therefore effective on the pain of lactation and should be integrated into the therapeutic armamentarium.
====
Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo
Rheumatology (Oxford) 2004 May;43(5):577-82 (ISSN: 1462-0324)
Bell IR; Lewis DA; Brooks AJ; Schwartz GE; Lewis SE; Walsh BT; Baldwin CM
Objective. To assess the efficacy of individualized classical homeopathy in the treatment of fibromyalgia. Methods. This study was a double-blind, randomized, parallel-group, placebo-controlled trial of homeopathy. Community-recruited persons (N = 62) with physician-confirmed fibromyalgia (mean age 49 yr, s.d. 10 yr, 94% women) were treated in a homeopathic private practice setting. Participants were randomized to receive oral daily liquid LM (1/50 000) potencies with an individually chosen homeopathic remedy or an indistinguishable placebo. Homeopathic visits involved joint interviews and concurrence on remedy selection by two experienced homeopaths, at baseline, 2 months and 4 months (prior to a subsequent optional crossover phase of the study which is reported elsewhere). Tender point count and tender point pain on examination by a medical assessor uninvolved in providing care, self-rating scales on fibromyalgia-related quality of life, pain, mood and global health at baseline and 3 months, were the primary clinical outcome measures for this report. RESULTS: Fifty-three people completed the treatment protocol. Participants on active treatment showed significantly greater improvements in tender point count and tender point pain, quality of life, global health and a trend toward less depression compared with those on placebo. CONCLUSIONS: This study replicates and extends a previous 1-month placebo-controlled crossover study in fibromyalgia that pre-screened for only one homeopathic remedy. Using a broad selection of remedies and the flexible LM dose (1/50 000 dilution factor) series, the present study demonstrated that individualized homeopathy is significantly better than placebo in lessening tender point pain and improving the quality of life and global health of persons with fibromyalgia.
============
Beckmann-Reinhold A, Schauer U, Wellensiek B, Werner B, Wartenberg A
A homeopathic complex remedy proves efficacious in migraine therapy: a randomized, double blind, parallel group clinical trial.
Headache World, 2000 ;London. Sept 3-7
Objectives: To assess the efficacy and safety of a homeopathic complex remedy compared with placebo in patients with migraine.
Design: Randomized, double-blind, parallel group trial for 20 weeks. Run-in for 4 weeks, 12 weeks of medication and 4 weeks of follow-up examination. Additional, defined medication (triptane, analgesics) was allowed if necessary and was documented by patients in a diary, additionally in an electronic pain recorder system.
Participants: 70 migraine patients (both sexes) with minimum 4 migraine attacks per month. Duration of illness must be more than 1 year. Any migraine prophylaxis was excluded.
Intervention: A homeopathic mixture of Iris Dil.D3, Gelsemium Dil.D4, Cyclamen Dil.D4, Paris quadrifolia Dil.D4, and Asarum europaeum Dil.D4 (three times daily 15 drops) or placebo (three times daily 15 drops) or placebo (three times daily 15 drops).
Aim of treatment: Frequency of migraine attacks and decrease of defined medication.
Results: The main interim results, including 42 of 70 patients. Verum was more effective in decreasing frequency of migraine attacks and reducing defined medication (triptane, analgesics). These reductions were statistically significant. Evaluation of effectiveness and safety by doctors and patients was comparable and verum was significantly better than placebo.
Conclusion: Additional application of homeopathic complex remedy proved to be significant in reducing number of migraine attacks and led to a significant reduction of triptane and analgesics.
Далее - см. комменты, туда добавляются более свежие публикации.
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no subject
Date: 2004-06-18 05:22 pm (UTC)Я правильно понимаю, что MTBI - это неспецифическая травма, т.е. включает любые травматические повреждения мозга в любом возрасте?
no subject
Date: 2004-06-19 12:25 am (UTC)no subject
Date: 2004-06-20 11:08 pm (UTC)Опс - а куда делась моя ссылка по лечению отита?
Date: 2004-06-24 06:40 am (UTC)Homeopathic treatment of acute otitis media in children: a preliminary randomized placebo-controlled trial
Pediatr Infect Dis 2001 ;20(2):177-183
Abstract
Methods. A randomized double blind placebo, control pilot study was conducted in a private pediatric practice in Seattle, WA. Seventy-five children ages 18 months to 6 years with middle ear effusion and ear pain and/or fever for no more than 38 h were entered into the study. Children received either an individualized homeopathic medicine or a placebo administered orally three times daily for 5 days, or until symptoms subsided, whichever occurred first. Out-come measures included the number of treatment failures after 5 days,2 weeks and 6 weeks. Diary symptom scores during the first days and middle ear effusion at 2 and 6 weeks after treatment were also evaluated
Results. There were fewer treatment failures in the group receiving homeopathy after 5 day, 2 weeks and 6 weeks with differences of 11.4, 18.4 and 19.9%, respectively, but these differences were not statistically significant. Diary scores showed a significant decrease In symptoms at 24 and 64 h after treatment in favor of homeopathy (P < 0.05).
Homeopathy for childhood diarrhea
Date: 2004-07-02 09:31 am (UTC)Pediatr Infect Dis J 2003 Mar;22(3):229-34 (ISSN: 0891-3668)
Jacobs J; Jonas WB; Jimenez-Perez M; Crothers D
Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA. jjacobs@igc.org.
BACKGROUND: Previous studies have shown a positive treatment effect of individualized homeopathic treatment for acute childhood diarrhea, but sample sizes were small and results were just at or near the level of statistical significance. Because all three studies followed the same basic study design, the combined data from these three studies were analyzed to obtain greater statistical power. METHODS: Three double blind clinical trials of diarrhea in 242 children ages 6 months to 5 years were analyzed as 1 group. Children were randomized to receive either an individualized homeopathic medicine or placebo to be taken as a single dose after each unformed stool for 5 days. Parents recorded daily stools on diary cards, and health workers made home visits daily to monitor children. The duration of diarrhea was defined as the time until there were less than 3 unformed stools per day for 2 consecutive days. A metaanalysis of the effect-size difference of the three studies was also conducted. RESULTS: Combined analysis shows a duration of diarrhea of 3.3 days in the homeopathy group compared with 4.1 in the placebo group (P = 0.008). The metaanalysis shows a consistent effect-size difference of approximately 0.66 day (P = 0.008). CONCLUSIONS: The results from these studies confirm that individualized homeopathic treatment decreases the duration of acute childhood diarrhea and suggest that larger sample sizes be used in future homeopathic research to ensure adequate statistical power. Homeopathy should be considered for use as an adjunct to oral rehydration for this illness.
no subject
Date: 2004-07-03 10:30 pm (UTC)так не явлется комплексным препаратом эуфорбиум ( он из молочая )помогает при заболевании ушей и носа, восп. гортани, катары, синуситы ...
о эффективности гомеопатии читайте на сайтах гомеопаческих...ими полон интернет...
важно найти хорошего гомеопата...к сожалению то, чем занимаются так называемые центры гомеопатии , о которых я знаю в Москве, к гомеопатии отношение имеет весьма слабое, а денег там дерут достаточно...если Вы пойдете в медицинскую книгу и там полистаете книги, а еще лучше купите их и станете изучать гомеопатию , вы сможете помочь своему ребенку лучше, чем эти лже-гомеопаты!
Всех благ!
no subject
Date: 2004-08-20 12:58 pm (UTC)Inflammation Research
Publisher: Birkhäuser Verlag AG
ISSN: 1023-3830 (Paper) 1420-908X (Online)
DOI: 10.1007/s00011-003-1242-0
Issue: Volume 53, Number 5
Date: April 2004
Pages: 181 - 188
Original Paper
Histamine dilutions modulate basophil activation
P. Belon1, J. Cumps2, M. Ennis3 , P. F. Mannaioni4, M. Roberfroid5, J. Sainte-Laudy6 and F. A. C. Wiegant7
(1) Boiron, 20 rue de la Libération, 69110 Sainte-Foy-Les-Lyon, France
(2) UCL 7369, 73 avenue Emmanuel Mounier, 1220 Brussels, Belgium
(3) Department of Clinical Biochemistry, Institute of Clinical Science, The Queens University of Belfast, Grosvenor Road, BT12 6BJ Belfast, United Kingdom
(4) Department of Pharmacology, Pieraccini 6, 50139 Florence, Italy
(5) Laboratoire de biotoxicologie, 73 avenue Emmanuel Mounier, 1220 Brussels, Belgium
(6) Laboratoire dImmunologie et dAllergologie, 5 boulevard Montparnasse, 75006 Paris, France
(7) Department of Molecular Cell Biology, University of Utrecht, 3508 Utrecht, The Netherlands
Received: 11 December 2002 Accepted: 12 November 2003 Published online: 21 April 2004
Abstract Background:In order to demonstrate that high dilutions of histamine are able to inhibit basophil activation in a reproducible fashion, several techniques were used in different research laboratories.
Objective:The aim of the study was to investigate the action of histamine dilutions on basophil activation.
Methods:Basophil activation was assessed by alcian blue staining, measurement of histamine release and CD63 expression. Study 1 used a blinded multi-centre approach in 4 centres. Study 2, related to the confirmation of the multi-centre study by flow cytometry, was performed independently in 3 laboratories. Study 3 examined the histamine release (one laboratory) and the activity of H2 receptor antagonists and structural analogues (two laboratories).
Results:High dilutions of histamine (10–30–10–38 M) influence the activation of human basophils measured by alcian blue staining. The degree of inhibition depends on the initial level of anti-IgE induced stimulation, with the greatest inhibitory effects seen at lower levels of stimulation. This multicentre study was confirmed in the three laboratories by using flow cytometry and in one laboratory by histamine release. Inhibition of CD63 expression by histamine high dilutions was reversed by cimetidine (effect observed in two laboratories) and not by ranitidine (one laboratory). Histidine tested in parallel with histamine showed no activity on this model.
Conclusions:In 3 different types of experiment, it has been shown that high dilutions of histamine may indeed exert an effect on basophil activity. This activity observed by staining basophils with alcian blue was confirmed by flow cytometry. Inhibition by histamine was reversed by anti-H2 and was not observed with histidine these results being in favour of the specificity of this effect We are however unable to explain our findings and are reporting them to encourage others to investigate this phenomenon.
Basophils - histamine - high dilutions - cimetidine - ranitidine - histidine
Received 11 December 2002; returned for revision 29 January 2003; accepted by A. Falus 12 November 2003
------------------------------------------------------------------
M. Ennis
Email: m.ennis@qub.ac.uk
no subject
Date: 2004-09-10 08:24 am (UTC)By Steve Connor, Science Editor
http://news.independent.co.uk/world...sp?story=552905
19 August 2004
To some it is the snake oil of the New Age. To others it is a tried-and-trusted treatment that has been good enough for the likes of Bill Clinton, the Prince of Wales, Geri Halliwell and David Beckham.
Homoeopathy is big business and getting bigger. Yet there is little if any evidence to show that it works, and absolutely nothing to justify its central claim - that highly diluted solutions containing nothing but water can affect human health.
That is until now. Researchers have just published what could be the first hard evidence in a peer-reviewed scientific journal that appears to support the central idea behind homoeopathy.
The scientists, from Britain, France, Belgium, Italy and the Netherlands, have chosen the relatively obscure but respected Inflammation Research to publish what some call the "holy grail" of homoeopathy.
In summary, the study found that extremely dilute solutions can have a biological effect. Like homoeopathic remedies, the solutions in the experiments were so diluted that there was no realistic chance of a single molecule of the substance remaining in the liquid.
Scientists have likened this to believing in magic. How could something that was once dissolved in a solution, and can no longer be present in that solution, still have an effect? The scientists themselves are baffled. "We are not yet able to propose any theoretical explanation of these findings," they write. In showing that high dilutions exert a biological effect, the findings seem to break the laws of physics. Surely there must be errors in the experiment; an accusation the scientists reject. "Despite searching for artefacts, we have been unable to find any," they write.
An editorial in Inflammation Research explains why the journal published such controversial research: "The authors are unable to explain their findings but wished to encourage others to investigate this area," it says. "It is with this spirit of openness that the journal, after submitting the paper to a rigorous reviewing process, has agreed to publish the paper."
Understandably, the practitioners of homoeopathy have seized on the findings as vindication. Peter Fisher, of the Royal Homoeopathic Hospital in London and homoeopath to the Queen, said the findings were nothing short of groundbreaking. "History may come to view [the study] as a turning point in the scientific controversy surrounding homoeopathy," Dr Fisher said.
"Of course further repetition is required, but it may be that this represents the holy grail of basic research in homoeopathy," he said.
There are two central tenets of homoeopathy. The first is that an illness or malady can be treated by administering tiny amounts of a substance that might under normal circumstances actually result in similar symptoms - extract of onion for instance to treat hay fever.
The second belief is that the concentrations have to be really minute, so minute that the dilutions involved in effect get rid of the substance in question from the liquid solvent.
Homoeopathic solutions are diluted repeatedly to produce solutions that are millions of times weaker than they were originally. Often the solutions are so weak that they are equivalent to dissolving a tiny speck of something in a volume of water several times greater than all the world's oceans.
Scientifically, this would mean that the chance of just a single molecule of the homoeopathic remedy being left in the solution is next to nil. Sceptics say patients might just as well treat themselves with distilled water - which is cheaper.
no subject
Date: 2004-09-10 08:31 am (UTC)However, the then editor of Nature, Sir John Maddox, had insisted that he would only agree to publication if he was able to investigate Dr Benveniste's laboratory procedures. A few weeks later Sir John invited an American science fraud investigator, Walter Stewart, and a professional magician and arch sceptic, James Randi, to watch over Dr Benveniste as he and his team tried to repeat the experiments.
The Nature investigation concluded that Dr Benveniste had failed to replicate his original study. In subsequent issues of Nature, Dr Benveniste suffered the professional ignominy of being ridiculed by arguably the most influential scientific journal in the world.
As a result, the idea of memory water was consigned to the dustbin of science history, or so it was thought.
France as a country is a keen advocate of homoeopathy and there were many French scientists who had not given up on the notion of investigating the phenomenon. Among them was a one-time collaborator of Dr Benveniste called Philippe Belon, who now works for a French homoeopathy company, Boiron.
Dr Belon, who fell out with Dr Benveniste a long time ago, has investigated high dilutions for 20 years and although he works for Boiron, and has himself tried homoeopathic remedies, he insists he is only interested discovering the truth about the claims.
In the spirit of scientific investigation he organised a collaboration between four different groups in Europe who all undertook to carry out identical high dilution experiments at separate places involving separate teams of scientists.
The British end was run by Professor Madeleine Ennis, an established asthma researcher at Queen's University of Belfast and an avowed sceptic of all things homoeopathic.
In fact Professor Ennis became involved in the project in the first place because she could not accept what some of her scientific colleagues were saying. "I told people I didn't believe it so they said 'why don't you try it'," Professor Ennis said.
The dilution experiments they carried out, and now published in Inflammation Research, involved a substance called histamine which is released by a type of white blood cell called a basophil. Normally basophils release histamine, and as levels of histamine rise this exerts a "negative feedback" which inhibits further release of histamine.
The four teams of scientists tested highly dilute solutions of histamine to see whether they still exert an effect on basophils in a test tube. At extreme dilutions, three out of four laboratories found a statistically significant effect and the fourth found an effect which just fell out of the typical range for statistical significance.
Professor Ennis emphasised that the research does not prove that homoeopathy works, nor does it even show that Dr Benveniste was right because he had used a different test for a high-dilution effect. "The paper didn't test homoeopathy, it tested high dilutions of histamine. I know what we tested and I cannot explain the results," said Professor Ennis.
For Dr Belon, however, the research does at least support the basic premise behind homoeopathy. "Of course it supports it, on the other hand it is not a demonstration that homoeopathy works," he said.
In whatever ways the latest findings are interpreted, they cannot be ignored. The experiments were repeated by four different teams using the same experimental protocol that involved a blind code - the scientists did not know whether they were working with a high dilution solution or a control sample of pure water until the code was broken at the end of the experiment.
no subject
Date: 2004-09-10 08:32 am (UTC)This time, with a full scientific paper detailing the precise protocol, anyone can try to replicate the findings - and replication is the essence of science. Until others repeat the work it will take a lot to convince sceptics such as James Randi, who has offered $1m to the first person to prove the scientific basis of homoeopathy.
Mr Randi warns about reading too much in a single scientific paper. "A paper is a paper is a paper. Don't forget, two scientists wrote a paper, published in Nature, back in 1974, that endorsed the powers of Uri Geller," he said.
But the homoeopathic gauntlet has been thrown down. The question now is whether anyone will be brave enough to pick it up.
no subject
Date: 2004-09-17 02:58 am (UTC)Title: Neuroprotection from glutamate toxicity with ultra-low dose glutamate
Neuropharmacology and neurotoxicology 2001 ; 2 (12) : 335-339
Abstract
The protective effects of ultra low doses (ULD) of glutamate against glutamate toxicity was studied in primary rat spinal, cortical and cerebellar neurons. Neurons were exposed to four, subtoxic, ultra-low concentrations of glutamate (10-18 M, 10 -20 M,10 -22 M and 10 -30 M) for 72 h and then subsequently challenged with toxic concentrations (25uM) of glutamate. Neuron viability was consistently 10% higher in the spinal and cortical neurons pre-exposed to glutamate concentrations of 10-18 M, and 10 -22 M, and in cerebellar neurons pre exposed to 10 -20 M and 10 -30 M. Using laser scanning confocal microscopy and the fluorescent calcium probe fluo-3, we found no alterations in intracellular calcium dynamics in the protected cells. This protective effect is consistent with a growing body of evidence for tolerance induced by low-dose toxin exposure but is the first time that such tolerance has been demonstrated with ultra-low glutamate exposure. Our data show that pre-exposure of neuronal cells to ULD glutamate can protect against subsequent exposure to toxic levels of glutamate.
no subject
Date: 2005-07-28 01:45 pm (UTC)no subject
Date: 2005-07-28 06:53 pm (UTC)Мистер Рэнди ответил на научные публикации (четыре независимые группы производили исследования по опубликованному протоколу) так:
"A paper is a paper is a paper".
Полагаю, это его окончательная позиция.
Вопрос следующий.
Date: 2005-07-30 03:48 pm (UTC)То есть сначала эффективность гомеопатического средства подтверждается в одной публикации - а потом это же средство другими гомеопатами в другой публикации (на других людях и другой выборке, но тоже с использованием двойного слепого)
Пока же все достижения можно объяснить знаменитым эффектом конкурса -
если сделать 1000 исследований с доверительным интервалом 95% -
то в 50 из них будет подтвержена
эффективность -
хотя на самом деле её нет. А публикуются только успешные исследования.
Re: Вопрос следующий.
Date: 2005-07-30 07:04 pm (UTC)Эффективность гомеопатических комплексов (комплексы имеют значительно меньшую эффективность, особенно стандартные) in vivo описываемым Вами способом была подтверждена, например, для Траумеля.
А вот in vitro действие гомеопатических разведений было подтверждено четырьмя независимыми группами исследователей (в т.ч. и не-гомеопатами)- данные сведения опубликованы в комментариях к этому посту, речь идет о сверхвысоких разведениях гистамина.
Re: Вопрос следующий.
Date: 2005-08-01 01:51 am (UTC)Существуют ли метаисследования (разные авторы), которые учитывали
бы индивидуализацию (тройной слепой) и доказывали бы эффективность метода?
no subject
Date: 2005-08-01 04:36 am (UTC)Frass M, Linkesch M, Banyai S, Resch G, Dielacher C, Lobl T, Endler C, Haidvogl M, Muchitsch I, Schuster E.
Ludwig Boltzmann Institute for Homeopathy, Graz, Austria. michael.frass@kabsi.at
BACKGROUND: Mortality in patients with severe sepsis remains high despite the development of several therapeutic strategies. The aim of this randomized, double-blind, placebo-controlled trial was to evaluate whether homeopathy is able to influence long-term outcome in critically ill patients suffering from severe sepsis. METHODS: Seventy patients with severe sepsis received homeopathic treatment (n = 35) or placebo (n = 35). Five globules in a potency of 200c were given at 12h interval during the stay at the intensive care unit. Survival after a 30 and 180 days was recorded. RESULTS: Three patients (2 homeopathy, 1 placebo) were excluded from the analyses because of incomplete data. All these patients survived. Baseline characteristics including age, sex, BMI, prior conditions, APACHE II score, signs of sepsis, number of organ failures, need for mechanical ventilation, need for vasopressors or veno-venous hemofiltration, and laboratory parameters were not significantly different between groups. On day 30, there was non-statistically significantly trend of survival in favour of homeopathy (verum 81.8%, placebo 67.7%, P= 0.19). On day 180, survival was statistically significantly higher with verum homeopathy (75.8% vs 50.0%, P = 0.043). No adverse effects were observed. CONCLUSIONS: Our data suggest that homeopathic treatment may be a useful additional therapeutic measure with a long-term benefit for severely septic patients admitted to the intensive care unit. A constraint to wider application of this method is the limited number of trained homeopaths.
Re: Вопрос следующий.
Date: 2005-08-01 05:01 am (UTC)Lancet. 1997 Sep 20;350(9081):834-43.
Are the clinical effects of homeopathy placebo effects? A meta-analysis of placebo-controlled trials.
Linde K, Clausius N, Ramirez G, Melchart D, Eitel F, Hedges LV, Jonas WB.
Munchener Modell, Centre for Complementary Medicine Research, Technische Universitat/Ludwig-Maximillans-Universitat, Munchen, Germany.
BACKGROUND: Homeopathy seems scientifically implausible, but has widespread use. We aimed to assess whether the clinical effect reported in randomised controlled trials of homeopathic remedies is equivalent to that reported for placebo. METHODS: We sought studies from computerised bibliographies and contracts with researchers, institutions, manufacturers, individual collectors, homeopathic conference proceedings, and books. We included all languages. Double-blind and/or randomised placebo-controlled trials of clinical conditions were considered. Our review of 185 trials identified 119 that met the inclusion criteria. 89 had adequate data for meta-analysis, and two sets of trial were used to assess reproducibility. Two reviewers assessed study quality with two scales and extracted data for information on clinical condition, homeopathy type, dilution, "remedy", population, and outcomes. FINDINGS: The combined odds ratio for the 89 studies entered into the main meta-analysis was 2.45 (95% CI 2.05, 2.93) in favour of homeopathy. The odds ratio for the 26 good-quality studies was 1.66 (1.33, 2.08), and that corrected for publication bias was 1.78 (1.03, 3.10). Four studies on the effects of a single remedy on seasonal allergies had a pooled odds ratio for ocular symptoms at 4 weeks of 2.03 (1.51, 2.74). Five studies on postoperative ileus had a pooled mean effect-size-difference of -0.22 standard deviations (95% CI -0.36, -0.09) for flatus, and -0.18 SDs (-0.33, -0.03) for stool (both p < 0.05).
INTERPRETATION: The results of our meta-analysis are not compatible with the hypothesis that the clinical effects of homeopathy are completely due to placebo.
no subject
Date: 2005-08-03 11:22 am (UTC)т.е. вопрос скорее в том, почему они сами его не пригласят и не закроют это дело.
no subject
Date: 2005-08-03 06:56 pm (UTC)Мне неясно, для чего "им" приглашать г-на Рэнди. Заработать на этом особо не удастся - подобная серия исследований стоит несколько сот тысяч; а вот вывести рез-ты и собственную репутацию из разряда "научных" в разряд "шоу" - запросто. К тому же Вы предполагаете почему-то добросовестность этого господина, в чём я лично сомневаюсь.
Treatment of seasonal allergic rhinitis using homeopathic preparation of common allergens
Date: 2009-05-28 01:49 pm (UTC)Treatment of seasonal allergic rhinitis using homeopathic preparation of common allergens in the southwest region of the US: a randomized, controlled clinical trial.
Kim LS, Riedlinger JE, Baldwin CM, Hilli L, Khalsa SV, Messer SA, Waters RF.
Southwest College Research Institute, Southwest College of Naturopathic Medicine & Health Sciences, Tempe, AZ 85282-1751, USA. l.kim@scnm.edu
BACKGROUND: Studies using homeopathy have reported beneficial effects from treating allergy-related conditions. OBJECTIVE: To investigate the effects of a homeopathic drug prepared from common allergens (tree, grass, weed species) specific to the Southwest region of the US. METHODS: A 4-week, double-blind clinical trial comparing homeopathic preparations with placebo was conducted in the Phoenix metropolitan area during the regional allergy season from February to May. Participants included 40 men and women, 26-63 years of age, diagnosed with moderate to severe seasonal allergic rhinitis symptoms. Study outcomes included allergy-specific symptoms using the rhinoconjunctivitis quality-of-life questionnaire (RQLQ), functional quality of life using the Medical Outcomes Study Short Form-36 (MOS SF-36), and the work productivity and activity impairment (WPAI) questionnaire. RESULTS: Scales from the RQLQ, MOS SF-36, and WPAI questionnaire showed significant positive changes from baseline to 4 weeks in the homeopathic group compared with the placebo group (p < 0.05). Subjects reported no adverse effects during the intervention period. CONCLUSIONS: These preliminary findings indicate potential benefits of the homeopathic intervention in reducing symptoms and improving quality of life in patients with seasonal allergic rhinitis in the Southwestern US.
Серия публикация в Evidence Based Complementary and Alt. Medicine
Date: 2009-05-28 01:54 pm (UTC)Immunology and Homeopathy. 4. Clinical Studies—Part 2
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1697745
Homeopathic care for the prevention of upper respiratory tract infections in children:
Date: 2009-05-28 02:01 pm (UTC)Homeopathic care for the prevention of upper respiratory tract infections in children: a pragmatic, randomised, controlled trial comparing individualised homeopathic care and waiting-list controls.
Steinsbekk A, Fønnebø V, Lewith G, Bentzen N.
Department of Public Health and General Practice, Norwegian University of Science and Technology (NTNU), MTFS, N-7489 Trondheim, Norway. aslak.steinsbekk@ntnu.no
OBJECTIVE: To investigate whether individualised treatment by homeopaths is effective in preventing childhood upper respiratory tract infection (URTI). METHODS: Open, pragmatic, randomised parallel-group trial with waiting-list group as control. One hundred and sixty-nine children below the age of 10 years, recruited by post from children previously diagnosed with URTI, were randomly assigned to receive either pragmatic homeopathic care from one of five homeopaths for 12 weeks or to a waiting-list control using self-selected, conventional health care. RESULT: There was a significant difference in median total symptom score in favour of homeopathic care (24 points) compared to the control group (44 points) (p = 0.026). The difference in the median number of days with URTI symptoms was statistically significant with 8 days in the homeopathic group and 13 days in the control group (p = 0.006). There was no statistical difference in the use of conventional medication or care between the two groups. CONCLUSION: In this study, there was a clinically relevant effect of individualised homeopathic care in the prevention of URTI in children.
воспроизведение результатов
Date: 2009-05-28 02:07 pm (UTC)Inhibition of CD203c membrane up-regulation in human basophils by high dilutions of histamine: a controlled replication study.
Chirumbolo S, Brizzi M, Ortolani R, Vella A, Bellavite P.
Department of Morphological and Biomedical Science, University of Verona, Piazza L.A: Scuro, 10, 37134, Verona, Italy.
OBJECTIVE: Previous research suggests that human basophil activation may be inhibited by histamine even at extremely low doses (high dilutions). However, uncertainties about the nature of the phenomenon and its reproducibility mean that further, rigorously controlled studies are necessary. METHODS: Serial 1:100 (v:v) histamine dilutions (centesimal dilutions, C) and water controls were tested on human basophil responsiveness to anti-IgE antibodies, using flow cytometry. Each dilution step was followed by vertical mechanical shaking (also designed as succussion) at 20 strokes/s. Basophil-enriched buffy coats from healthy blood donors were incubated with 10(-4) mol/l histamine (2C) and with serially diluted preparations from 10(-20) mol/l (10C) to 10(-32) mol/l (16C), then incubated for 30 min with 1 mug/ml goat monoclonal anti-human IgE and basophils stained for immunophenotyping. RESULTS: Membrane up-regulation of CD203c, which in these experimental conditions proved to be a more consistent activation marker than CD63, was significantly inhibited in samples treated with histamine at the dilutions of 2C (P = 0.001), 12C (P = 0.047), 14C (P = 0.003), 15C (P = 0.036) and 16C (P = 0.009). Control water dilutions/succussions did not show any significant effect. CONCLUSION: Using a strictly standardized flow cytometry protocol and a new dilution/succussion procedure, we have shown that low and high dilutions of histamine inhibit CD203c up-regulation in anti-IgE stimulated basophils.
Re: Серия публикация в Evidence Based Complementary and Alt. Medicine
Date: 2009-05-28 02:10 pm (UTC)